Simultaneous Detection of Multiple Biomarkers Using SERS-Based Immunoanalysis

Simultaneous detection of duplex DNA oligonucleotides using a SERS-based micro-network gradient chip.

We report the development of a programmable surface-enhanced Raman scattering (SERS)-based micro-network gradient platform to simultaneously detect two different types of DNA oligomer mixtures. The utility of this platform was demonstrated by quantitative analysis of two breast cancer-related (BRCA1) DNA oligomer mixtures. To generate on-demand concentration gradients, the microfluidic circuit ...

Electronic Supplementary Information Ultrasensitive SERS sensor for simultaneous detection of multiple cancer-related miRNAs

Sensitive multiplex detection of serological liver cancer biomarkers using SERS-active photonic crystal fiber probe.

Surface-enhanced Raman scattering (SERS) spectroscopy possesses the most promising advantage of multiplex detection for biosensing applications, which is achieved due to the narrow 'fingerprint' Raman spectra from the analyte molecules. We developed an ultrasensitive platform for the multiplex detection of cancer biomarkers by combining the SERS technique with a hollow-core photonic crystal fib...

Actively Targeted In Vivo Multiplex Detection of Intrinsic Cancer Biomarkers Using Biocompatible SERS Nanotags

Surface-enhanced Raman scattering (SERS) technique is becoming highly popular for multiplex biosensing due to the 'fingerprint' Raman spectra from every molecule. As a proof-of-concept, we demonstrated the actively targeted multiplex in vitro and in vivo detection of three intrinsic cancer biomarkers - EGFR, CD44 and TGFβRII in a breast cancer model using three multiplexing capable, biocompatib...

Detection of power oscillation and simultaneous faults using Clark transform

Distance relays are widely used to protect transmission lines. Sometimes, in these lines due to the occurrence of the oscillation of the power, the impedance calculated in the distance relay enters into its functional zones and leads to the cutting off of the lines. This issue can cause global power outages. Accordingly, in this paper, a Clark-based method for detecting the oscillation of power...